Hunter College of the City University of New York-Department of Biological Scienceswebsite for course: http://maxweber.hunter.cuny.edu/eres/
Seminar in Developmental Genetics
Room: Biology Seminar Room A. Henderson (ROOM 834HN)
Wednesday 9:10-11:00 Henderson@genectr.hunter.cuny.edu
| Lect | Date | Topic | Lecturer | Reading | Internet sources |
| 1 | 2/2 | Organization; An introduction to developmental genetics | Henderson | A quick overview of some of the scientists we will be talking about, as well as some rather dour photos, can to be found in Gilbert, Developmental Biology, fifth edition, Chapter 2. | http://maxweber.hunter.cuny.edu/eres/
http://www.acs.ucalgary.ca/~browder/gameto.html http://zygote.swarthmore.edu/index.html |
| 2 | 2/9 | Induction and the origins of developmental genetics | Henderson | ||
| 3 | 2/16 | Induction and the origins of developmental genetics | Henderson | ||
| 4 | 2/23 | Research time.. on your own | |||
| 5 | 3/1 | Research time.. on your own | Henderson is available for consultation during office hours | ||
| 6 | 3/8 | Nucleus or cytoplasm: which controls heredity? Contributions of Driesch, Herbst, Roux, Weismann, Boveri, Stevens, Morgan | From: A Conceptual History of Modern Embryology (S. F. Gilbert, ed.) Plenum Press, NY. | http://www.ucalgary.ca/UofC/eduweb/virtualembryo/roots.html
http://www.acs.ucalgary.ca/~browder/gameto.html http://zygote.swarthmore.edu/index.html |
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| 7 | 3/15 | Origins of Induction: Contributions of Spemann, Harrison, Hamburger, Holtfreter, Goldschmidt, Just | From: A Conceptual History
of Modern Embryology (S. F. Gilbert, ed.) Plenum Press, NY. pp. 181-206.
Scott F. Gilbert, Cellular Politics: the Attempt to Reconcile Embryology and Genetics; Ernest Everett Just, Richard B. Goldschmidt, and In The American Development of Biology 1988. (R. Rainger, K. R. Benson, and J. Maienschein, eds.) University of Pennsylvania Press, Philadelphia. Pp. 311-346. Gluecksohn-Waelsch, S., 1981, Viktor Hamburger and developmental genetics, Hamburger Festschrift, Oxford University Press, New York, pp. 44-52. |
http://zygote.swarthmore.edu/gene3a.html | |
| 8 | 3/22 | The foundations of developmental genetics. Contributions of Dunn, Waelsch and Waddington | Bennett D., L. C. Dunn and
his contribution to T-locus genetics, Annual Rev Genet. 1977;11:1-12
Gluecksohn-Waelsch S. Fifty years of developmental genetics. Trans N Y Acad Sci. 1983;41:243-51. Waelsch, S., 1992. The causal analysis of development in the past half century: a personal history. Development, supplement 1-5, pgs 1-5 |
http://zygote.swarthmore.edu/index.html
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| 9 | 3/29 | Nucleus vs cytoplasm (phase
3-cloning and nuclear potency):
Briggs and King, Gurdon What recent advances in cloning technology have done to answer the questions raised by previous studies |
Briggs, R. and T.J. King, 1952. Transplantation of living nuclei from blastula cells into eunucleated frogs' eggs. Proc. Nat. Acad, Sci. USA 38, 455-463. | http://home.hawaii.rr.com/johns/history.htm#BM1962 | |
| 10 | 4/5 | OPEN TOPIC
Molecular concepts of induction - what is the T-box? |
Gluecksohn-Waelsch S, et al.
The T-locus of the mouse: implications for mechanisms of development.
Curr Top Dev Biol. 1970;5:281-316;
Papaioannou VE, et al. The T-box gene family. Bioessays. 1998 Jan;20(1):9-19. Review. Smith J T-box genes: what they do and how they do it.Trends Genet 1999 Apr;15(4):154-8 |
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| 11 | 4/12 | OPEN TOPIC
- The molecular organizer and inducer - what is HOX? |
Chapter 16 in Gilbert ;
Gellon, G. and McGinnis, W. (1998) Shaping the animal body plans in development and evolution by modulation of Hox expression patterns. Bioessays 20, 116; Carroll, S.B. (1998) From Pattern to Gene, Gene to Pattern. Special Issue of the International Journal of Developmental Biology on the Developmental Genetics of Drosophila, 42:305-309.; Fan, M. J., Sokol S.Y. (1997). A role for Siamois in Spemann organizer formation. Development 124, 2581-258 Hox genes and the global patterning of the somitic mesoderm. Curr Top Dev Biol. 2000;47:155-81 Conserved genetic programs in insect and mammalian brain development. Bioessays. 1999 Aug;21(8):677-84. Evolution of chordate hox gene clusters. Ann N Y Acad Sci. 1999 May 18;870:238-48. |
http://www.mssm.edu/molbio/hoxpro/new/hox-pro00.html |
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| 12 | 5/3 | OPEN TOPIC
The molecular organizer and inducer-What do Pax (paired homeobox) genes have to do with it? |
Transcription factors and cancer. The example of pax genes. Adv Clin Path 1997 Oct;1(4):243-255 | http://www.elsevier.co.jp/homepage/sah/mod/gxp/907/00000002.html
http://www.imolbio.oeaw.ac.at/xenopus/Marker_pages/CNS/Pax3.html |
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| 13 | 5/10 | OPEN TOPIC
- The molecular organizer and inducer-What does Wnt (and the rest of the family) have to do with it? |
Wodarz, A. and Nusse, R. (1998)
Mechanisms of Wnt signaling in Development. Annu Rev Cell Dev Biol 14:59-88;
Cadigan, K. and Nusse, R. (1997) Wnt signaling: a common theme in animal development. Genes & Dev. 11, 3286 |
http://www.stanford.edu/%7Ernusse/wntwindow.html |
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| 14 | 5/17 | OPEN TOPIC
- The molecular organizer and inducer-what is TGF-B and its family members doing? |
Derriere: a TGF-beta family
member required for posterior development in Xenopus. Development 1999
pr;126(7):1467-82 ;
Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J 1999 Dec;13(15):2105-24 BMP signalling in early Xenopus development. Bioessays 1999 Sep;21(9):751-60 |